About Marqués de Valdecilla University Hospital

Marqués de Valdecilla University Hospital

Articles by Marqués de Valdecilla University Hospital

Effect of hemodialysis session on acute changes in inflammatory and cardiovascular risk biomarkers

Published on: 9th January, 2020

OCLC Number/Unique Identifier: 9269418657

Background: Inflammation is associated with enhanced cardiovascular risk profile and increased cardiovascular mortality in end-stage kidney disease patients undergoing hemodialysis. Mechanisms of activated acute phase reaction in patients on chronic hemodialysis remain to be identified. As successful treatment of the inflammatory condition in these patients may improve long-term survival, we studied potential changes in different inflammatory biomarkers of cardiovascular risk in end-stage kidney disease patients after a mid-week hemodialysis session. Methods: Inflammatory biomarkers of cardiovascular risk (cystatin-C, homocysteine, C-reactive protein, procalcitonin, pentraxin-3, serum amyloid-A) and atherogenic plasma lipoproteins (Lipoprotein(a), cholesterol low and high density lipoproteins) were studied in 21 end-stage kidney disease patients previously and after a mid-week hemodialysis session. Results: We found a significant reduction in serum levels of low molecular weight molecules: cystatin-C (5.56 to 1.85 mg/L, 66.73%, p < 0.001), homocysteine (22.85 to 13.25 µmol/L, 42.01%, p < 0.001) and procalcitonin (0.788 to 0.457 ng/mL, 42.01%, p < 0.001). Large molecules as C-reactive protein (9.70 to 9.90 mg/L, 2.06%, p = 0.022) and pentraxin-3 (1.67 to 4.28 ng/mL, 156%, p < 0.001) increased, but serum amyloid-A decreased (15.90 to 12.70 mg/L, 20.13%, p < 0.05). There was no change in Lipoprotein (a) levels. Conclusion: Pentraxin-3 was a more specific inflammatory vascular marker than C-reactive protein, and the best inflammatory marker associated with hemodialysis. Homocysteine, procalcitonin and the other small proteins could be released and removed during hemodialysis session. Further studies are needed to understand the behavior and significance of these markers after successive hemodialysis.
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Bacteremia with the Triad Osteomyelitis, Deep Vein Thrombosis, and Pulmonary Septic Emboli in Pediatric Age: A Case Report

Published on: 25th October, 2025

Acute osteomyelitis (AOM) is defined as an inflammation of the bone secondary to infection. Among the most common complications of AOM is the development of a periosteal abscess and the extension of the focus locally to muscle (pyomyositis) and/or joint (osteoarthritis). However, complications with much lower incidence have been described, including deep vein thrombosis (DVT) and septic pulmonary embolisms (SPE), mainly associated with S. aureus infections. The AOM + DVT + ESP triad is a fairly uncommon entity in the pediatric population; however, if it is not diagnosed and treated in time, it implies a high morbidity and mortality. Treatment, which must be early and aggressive, includes targeted antibiotic therapy, anticoagulation, and focused control surgery. In this article, we describe the case of a 14-year-old boy with disseminated staphylococcal infection associated with the triad AOM+ DVT + SPE.
Cite this ArticleCrossMarkPublonsHarvard Library HOLLISGrowKudosResearchGateBase SearchOAI PMHAcademic MicrosoftScilitSemantic ScholarUniversite de ParisUW LibrariesSJSU King LibrarySJSU King LibraryNUS LibraryMcGillDET KGL BIBLiOTEKJCU DiscoveryUniversidad De LimaWorldCatVU on WorldCat
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