Cytogenetic and clinical features of longlivers with osteoarthritis from Precarpathian region (West Ukraine) for 1998-2014yy
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Abstract
Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide.
Aim of our study was to assess the clinical and the cytogenetic characteristics in longlivers with osteoarthritis from Precarpathian region (Ukraine).
Methods: Cytogenetic, Clinical
Results: All of the subjects were separated into three groups: І group - 146 longlivers patients who had hypertension and osteoarthritis (ОА); II group - 93 longlivers patients only with ОА. The control (third) group included 130 patients aged 90-102 years without osteoarthritis and hypertension in anamnesis. In the age group more than 95 years, men and women of both groups were significant difference (p<0,05) to be compared with control.
Cytogenetic characteristics of the long-livers with on osteoarthritis showed that most there is a tendency for a higher frequency of chromosomal aberrations in male long-livers and tere are significant difference among control (p<0,05). The number of chromosomes associated in a single cell was significantly higher (p<0,05) in both groups compared to control.
Conclusion: The importance of this study resides, to the best of our knowledge, in the fact that the largest group of patients in Ukraine was analyzed and assessed.
Article Details
Copyright (c) 2019 Kozovyy R, et al.
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Briggs AM, Page CJ, Shaw BR, Bendrups A, Philip K, et al. A Model of Care for Osteoarthritis of the Hip and Knee: Development of a System-Wide Plan for the Health Sector in Victoria, Australia. Healthc Policy. 2018; 14: 47-58. Ref.: https://tinyurl.com/y5q8w7jg
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014; 73: 1323–1330. Ref.: https://tinyurl.com/y2zy4fer
Frolov AK, Artsimovich NG, Sokhin AA. Immunocytogenetics. Medicine. 1993; 240.
Guzhevsky IV, Gerasimenkov SI, Magomedov AA, Panchenko LM. On the question of the local treatment of some types of primary gonarthrosis in adults [Article in Ukrainian] / Ukr J Clinical and Laboratory Medicine. 2009; 4: 70-74.
Huang D, Liu YQ, Liang LS, Lin XW, Song T, et al. The Diagnosis and Therapy of Degenerative Knee Joint Disease: Expert Consensus from the Chinese Pain Medicine Panel. Pain Res Manag. 2018; 2018: 2010129. Ref.: https://tinyurl.com/yxpwjan4
ISCN 2013. An International System for Human Cytogenetic Nomenclature (2013)/ LG Shaffer, J McGowan-Jordan, M Schmid // Karger.-2013; 137. Ref.: https://tinyurl.com/yy2766p2
Magnusson K, Turkiewicz A, Englund M. Nature vs nurture in knee osteoarthritis - the importance of age, sex and body mass index. Osteoarthritis Cartilage. 2019; 27: 586-592. Ref.: https://tinyurl.com/yx9x7lmm
Moorhead PS, Nowell PC, Mellman WJ, Battips DM, Hungerford DA. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 1960; 20: 613-616. Ref.: https://tinyurl.com/yyz2dcr8
Population of Ivano-Frankivsk. Ref.: https://tinyurl.com/y6bk4lyz
Postler A, Ramos AL, Goronzy J, Günther KP, Lange T, et al. Prevalence and treatment of hip and knee osteoarthritis in people aged 60 years or older in Germany: an analysis based on health insurance claims data. Clin Interv Aging. 2018; 13: 2339-2349. Ref.: https://tinyurl.com/y5gwwhgr
Povoroznyuk VV. Neuropathic pain component in patients of various age with knee osteoarthritis. 9th Congress of the European Pain Federation EFIC. Vienna, 2015: 396-397. Ref.: https://tinyurl.com/yyvrecza
Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971; 2: 971-972. Ref.: https://tinyurl.com/y66n7cn4
Meiner SE, Yeager JJ. Gerontologic Nursing - E-Book. Arthritis-Related Statistics: Prevalence of Arthritis in the United States". Centers for Disease Control and Prevention, US Department of Health and Human Services. 9 November 2016. Archived from the original on 29 December 2016. Ref.: https://tinyurl.com/y45tgk52
Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, et al. Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nat Genet. 2019; 51: 230-236. Ref.: https://tinyurl.com/y6z57ypj
Timmermans EJ, de Koning EJ, van Schoor NM, van der Pas S, Denkinger MD, et al. Within-person pain variability and physical activity in older adults with osteoarthritis from six European countries. BMC Musculoskelet Disord. 2019; 20: 12. Ref.: https://tinyurl.com/y3odr3cv
Thorlund JB, Turkiewicz A, Prieto-Alhambra D, Englund M. Opioid use in knee or hip osteoarthritis: a region-wide population-based cohort study. Osteoarthritis Cartilage. 2019; pii: S1063-4584(19)30030-5. Ref.: https://tinyurl.com/y3te5dtk
Wang X, Jin X, Han W, Cao Y, Halliday A, et al. Cross-sectional and longitudinal associations between knee joint effusion synovitis and knee pain in older adults. J Rheumatol. 2016; 43: 121-130. Ref.: https://tinyurl.com/y6e5mqdr
White DK, Lee J, Song J, Chang RW, Dunlop D. Potential functional benefit from light intensity physical activity in knee osteoarthritis. Am J Prev Med. 2017; 53: 689–696. Ref.: https://tinyurl.com/yypnvdb9
Zengini E, Hatzikotoulas K, Tachmazidou I, Steinberg J, Hartwig FP, et al. Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nat Genet. 2018; 50: 549-558. Ref.: https://tinyurl.com/y5vermzs
Zerova-Lyubimova TE, Gorovenko NG. Cytogenetic methods for the study of human chromosomes. Guidelines. [In Ukrainian] - Kyiv; 2003; 24